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Associate Professor of Biological Sciences, Ph.D.
Molecular and Cellular Pathology 2002: University of Wisconsin-Madison. Dr. Mothé started her appointment at CSUSM in Fall 2003. Dr. Mothé conducted her
postdoctoral work at Epimmune, Inc in San Diego, CA. Her areas of
specialization are immunology and virology, with research interests in
designing novel vaccines for rapidly mutating viruses, including HIV and SIV.
Research Students (dates research conducted in
lab)
Barbara Stewart (Masters student, 2004-2005) currently in
Ph.D. program in Biodefense at SUNY-Albany
Scott Worsley (Masters student, 2004-present)
Javier Fernandez (Masters student, 2005- present)
Stephanie Stogiera (Undergraduate student, 2003-2005)
currently in Ph.D. program at the University of Michigan
Melissa Thompson (Undergraduate student, 2003-2005)
currently
in Physician’s Assistant program in Pennsylvania
Alena Christina Ramirez (Undergraduate student, 2004-present)
Claudia Pawlowski (Undergraduate student, 2004-present)
Cynthia Basa-Morales (Undergraduate student, 2004-present)
PUBLICATIONS
Geisbert, T.W., Jones, S., Fritz, E.A.,
Shurtleff, A.C., Geisbert, J.B., Liebscher, R., Grolla, A., Stroher, U.,
Fernando, L., Daddario, K.M., Guttieri, M.C., Mothe, B.R.,
Larsen, T., Hensley, L.E., Jahrling, P.B., Feldmann, H. Development of a
new vaccine for the prevention of Lassa fever. PLoS Med. 2005
Jun;2(6):e183. Epub 2005 Jun 28.
Bui, H.H., Sidney, J., Peters, B., Sathiamurthy, M., Sinichi, A., Purton,
K.A., Mothe, B.R., Chisari, F.V., Watkins, D.I., Sette, A.
Automated generation and evaluation of specific MHC binding predictive
tools: ARB matrix applications. Immunogenetics. 2005 Jun;57(5):304-14.
Epub 2005 May 3.
Altfeld, M., Allen, T.M., Kalife, E., Frahm, N., Addo, M.M.,
Mothe,
B.R., Rathod, A., Reyor, L., Harlow, J., Yu, X., Perkins, B.,
Sidney, J., Alter, G., Lichterfeld, M., Sette, A., Rosenberg, E.S.,
Goulder, P.J.R., Brander, C., Walker, B.D. The majority of currently
circulating HIV-1 clade B viruses fail to prime CTL responses against an
otherwise immunodominant HLA-A2-restricted epitope. Journal of Virology.
2005 Apr;79(8):5000-5.
Tangri, S., Mothé, B.R., Eisenbraun, J., Sidney, J., Southwood,
S., Briggs, K., Zinckgraf, J., Bilsel, P., Newman, M., Chesnut, R.,
LiCalsi, C., Sette, A. Rationally Engineered Therapeutic Proteins with
Reduce Immunogenicity. Journal of Immunology. 2005 Mar
15;174(6):3187-96.
Sette, A, Sidney, J., Bui, H.-H., del Guercio, M.-F., Alexander, J.,
Loffredo, J., Watkins, D.I., and Mothé, B.R. Characterization of
the peptide-binding specificity of Mamu-A*11 results in the
identification of SIV-derived epitopes and interspecies
cross-reactivity. Immunogenetics. 2005 Apr;57(1-2):53-68. Epub 2005 Mar
4.
Loffredo, J.T., Sidney, J., Wojewoda, C., Dodds, E., Napoé, G.,
Mothé,
B.R., O’Connor, D.H., Wilson, N.A., Watkins, D.I., Sette, A.,
Seventeen New Simian Immunodeficiency Virus-Derived Cytotoxic
T-Lymphocyte Epitopes Identified by Refinement of the Peptide-Binding
Motif of the High Frequency Molecule, Mamu-A*02. Journal of Immunology.
2004 Oct 15;173(8):5064-76.
Allen, T.M., Altfeld, M., Yu, H.G.,
O’Sullivan, K.M., Lichterfeld, M., Lee, P., Le Gall, S., Mothé, B.R.,
Cohen, D.E., Freedberg, K.A., Sette, A., Rosenberg, E.S., Goulder, P.J.R.,
Brander, C., Walker, B.D. Selection. Transmission and Reversion of an
Antigen Processing CTL Escape Mutation in HIV-1. Journal of Virology.
2004 Jul;78(13):7069-78.
Friedrich, T.C., Dodds, E.J., Yant, L., Rudersdorf, R., Cullen, C.,
Evans, D.T., Desrosiers, R.C., Mothé, B.R., Sidney, J., Sette,
A., Kunstman, K., Wolinsky, S., Piatak, M., Lifson, J., McDermott, A.,
Wilson, N., O’Connor, D.H., Watkins, D.I. Reversion of transmitted
cytotoxic T-lymphocyte (CTL) escape variant immunodeficiency viruses in
vivo. Nat Med. 2004 Mar;10(3):275-81. Epub 2004 Feb 15.
O’Connor, D.H.*,
Mothé, B.R.*, Weinfurter, J.*, Fuenger, S.,
Rehrauer, W., Jing, P., Rudersdorf, R.A., Liebl, M.E., Krebs, K.,
Vasquez, J., Dodds, E., Loffredo, J., McDermott, A.B., Allen, T.M.,
Wang, C., Doxiadis, G.G.M., Montefiori, D.C., Burton, D.R., Allison, D.B.,
Wolinsky, S.M., Bontrop, R.E., Picker, L.J, Watkins, D.I.. MHC Class I
Alleles Associated With Slow SIV Disease Progression Restrict Dominant
Acute Phase Cytotoxic T Lymphocyte Responses. Journal of Virology, 2003
77:9029-40.
*These authors contributed equally
Mothé, B.R., Weinfurter, J., Wang, C., Rehrauer, W., Wilson, N.,
Allen, T.M., Allison, D.B., Watkins, D.I. Expression of the MHC class I
molecule Mamu-A*01 is Associated with Control of SIVmac239 Replication.
Journal of Virology. 2003 Feb.; 77(4):2736-40
Allen, T.M., Jing, P., Calore, B., Horton, H., O’Connor, D.H., Hanke,
T., Piekarczyk, M., Ruddersdorf, R., Mothé, B.R., Emerson, C.,
Wilson, N., Lifson, J.D., Belyakov, I.M., Berzofsky, J.A., Wang, C.,
Allison, D.B., Montefiori, D.C., Desrosiers, R.C.,Wolinsky, S., Kunstman,
K.J., Altman, J.D., Sette, A., McMichael, A.J., Watkins, D.I. Effects of
CTL Directed Against a Single SIV Gag CTL Epitope on the Course of
SIVmac239 Infection. Journal of Virology. 2002 Oct.; 76(20):10507-11
Mothé, B.R., Sidney, J., Dzuris, J.L., Liebl, M.E., Fuenger, S.,
Watkins, D.I., and Sette, A. Characterization of the peptide binding
specificity of Mamu-B*17 and identification of Mamu-B*17-restricted
epitopes derived from SIV proteins. Journal of Immunology. 2002.
169(1):210-219.
O'Connor, D.H., Allen, T.M., Vogel, T.U., Jing, P., DeSouza, I.P., Dodds,
E., Dunphy, E.J., Melsaether, C., Mothé, B., Yamamoto, H.,
Horton, H., Wilson N, Hughes, A.L., Watkins, D.I. Acute phase cytotoxic
T lymphocyte escape is a hallmark of simian immunodeficiency virus
infection. Nat Med. 2002. May;8(5):493-9.
Mothé, B.R.*, Horton, H.*, Carter, D.K., Allen, T.M., Liebl, M.E.,
Skinner, P., Vogel, T.U., Fuenger, S., Vielhuber, K., Rehrauer, W.,
Wilson, N., Franchini, G., Altman, J.D., Haase, A., Picker, L.J.,
Allison, D.B., Watkins, D.I. Dominance of CD8 Responses Specific For
Epitopes Bound by a Single MHC Class I Molecule During the Acute Phase
of Viral Infection. Journal of Virology, 2002 Jan.; 76 (2): 875-884.
*These authors contributed equally
Allen, T.M., Mortara, L., Mothé, B.R., Liebl, M., Jing, P.,
Calore, B., Piekarczyk, M., Ruddersdorf, R., O’Connor, D.H., Fuller, D.,
Wang, X., Altman, J.D., Sette, A., Desrosiers, R., Sutter, G., Watkins,
D.I. A DNA/MVA Vaccine Expressing Tat is Unable to Control Virus
Replication in SIVmac239 Challenged Rhesus Macaques. Journal of
Virology, 2002 April.; 76 (8): 4108-12.
Allen, T.M.*, Mothé, B.R.*, Sydney, J., Jing, P., Dzuris, J.L.,
Liebl, M.E., Vogel, T.U., O’Connor, D.H., Wang, X., Wussow, M.C.,
Thomson, J.A., Altman, J.D., Watkins, D.I., Sette, A. CD8+ Lymphocytes
From SIV-Infected Rhesus Macaques Recognize 27 Different Peptides Bound
by the MHC Class I Molecule Mamu- A*01: Implications for Vaccine Design
and Testing. Journal of Virology, 2001 Jan.; 75 (2): 738- 749.
*These authors contributed equally
Sidney, J., Dzuris, J., Newman, M., Johnson, R.P., Amitindir, K., Appela,
E., Mothé, B.R., Watkins, D.I., Sette, A. Definition of the Mamu-A*01
peptide binding specificity: application to the identification of wild
type and optimized ligands from SIV regulatory proteins. Journal of
Immunology, 2000 Dec 1; 165(11):6387-99.
Allen, T.M., O'Connor, D.H., Jing, P., Dzuris, J.L.,
Mothé, B.R.,
Vogel, T.U., Dunphy, E., Liebl, M.E., Emerson, C., Wilson, C., Kunstman,
K.J., Wang, X., Allison, D.B., Hughes, A.L., Desrosiers, R.C., Altman,
J.D., Wolinsky, S.M., Sette, A, Watkins, D.I. Tat- Specific Cytotoxic T
Lymphocytes Select for SIV Escape Variants During Resolution of Primary
Viraemia. Nature, 2000 Sep 21; 407(6802):386-90.
Allen, T.M., Vogel, T.U., Fuller, D.H.,
Mothé, B.R., Steffen, S.,
Boyson, J.E., Shipley, T., Fuller, J., Hanke, T., Sette, A., Altman,
J.D., Moss, B., McMichael, A.J., Watkins, D.I. Induction of AIDS
virus-specific CTL activity in fresh, unstimulated peripheral blood
lymphocytes from rhesus macaques vaccinated with a DNA Prime/Modified
vaccinia virus ankara boost regimen. Journal of Immunology, 2000 May
1;164(9):4968-78
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